An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of site-specific DNA-methyltransferase (adenine-specific), EC 2.1.1.72.
ChEBI ID: 65065
| Member | Definition | Class |
|---|---|---|
| s-adenosylhomocysteine | An organic sulfide that is the S-adenosyl derivative of L-homocysteine. | S-adenosyl-L-homocysteine zwitterion; S-adenosyl-L-homocysteine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 407 (29.39) | 18.7374 |
| 1990's | 206 (14.87) | 18.2507 |
| 2000's | 358 (25.85) | 29.6817 |
| 2010's | 355 (25.63) | 24.3611 |
| 2020's | 59 (4.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 20 (1.42%) | 5.53% |
| Reviews | 58 (4.11%) | 6.00% |
| Case Studies | 5 (0.35%) | 4.05% |
| Observational | 1 (0.07%) | 0.25% |
| Other | 1,328 (94.05%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI | Thermus aquaticus | Kd | 2.4000 | 1 | 2 |
| Chain A, Modification Methylase Rsri | Cereibacter sphaeroides | Kd | 8.1000 | 1 | 2 |
| Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase | Pisum sativum (garden pea) | Kd | 21.2000 | 1 | 1 |
| Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase | Pisum sativum (garden pea) | Kd | 21.2000 | 1 | 3 |
| Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI | Thermus aquaticus | Kd | 2.4000 | 1 | 1 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific | Homo sapiens (human) | Kd | 0.2550 | 2 | 2 |
| tRNA (cytosine(38)-C(5))-methyltransferase | Homo sapiens (human) | Kd | 13.6000 | 1 | 1 |
| tRNA (guanine-N(1)-)-methyltransferase | Mycobacterium tuberculosis H37Rv | Kd | 10.1000 | 1 | 1 |
| tRNA (guanine-N(1)-)-methyltransferase | Pseudomonas aeruginosa PAO1 | Kd | 5.9000 | 1 | 1 |
| tRNA (guanine-N(1)-)-methyltransferase | Staphylococcus aureus subsp. aureus NCTC 8325 | Kd | 3.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-methylthioadenosine/S-adenosylhomocysteine deaminase | Thermotoga maritima MSB8 | Km | 210.0000 | 1 | 1 |
| Adenosylhomocysteinase | Rattus norvegicus (Norway rat) | Km | 9.7000 | 1 | 1 |
| Adenosylhomocysteinase | Thermotoga maritima MSB8 | Km | 21.0000 | 1 | 1 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | Kis | 36.3000 | 1 | 1 |
| Histamine N-methyltransferase | Cavia porcellus (domestic guinea pig) | Kis | 18.1000 | 1 | 1 |